Do you want to participate in a paid research study from the comfort of our home?

The purpose of this research is to see whether you can decrease use of your regular cigarette with the use of either the flavored on!® nicotine pouches or the unflavored (Original) on!® nicotine pouches.

• Between the ages of 22-65
• Able to read, understand, and willing to sign an informed consent form (ICF) and complete questionnaires written in English
• Not pregnant, nursing, or planning to become pregnant
• Smokes 5 or more combustible cigarettes per day
• Has been smoking combustible cigarettes for a year or more
• Owns a smartphone with text message and data capabilities
• No current serious medical conditions

Your participation in this study will last approximately 7 weeks, with a 6-month follow-up questionnaire that is scheduled for 6 months after the end of the 7-week participation period.

You will be paid up to a total of approximately $1,020 if you complete this study and respond to all daily messages. If you do not complete the study, for any reason, you will be paid for the parts of the study you do complete according to the following schedule:

• Screening & Baseline Remote Visit (Maximum total $65)
• Baseline Period 3-7 Days (Maximum total $95)
• Week 1 (Maximum total $90)
• Week 2 (Maximum total $89)
• Week 3 (Maximum total $103)
• Week 4 (Maximum total $132)
• Week 5 (Maximum total $131)
• Week 6 (Maximum total $265)
• ·Six-Month Follow-Up (Maximum total $50)

If you agree to take part in this research study, information about your identity, health and your participation will be collected, recorded, and stored by study staff.

Rose Research Center, the FDA, the Sponsor, other health authorities, and the Institutional Review Board (IRB) may inspect your hard-copy and electronically stored research records which may include your name, address and other personal information that identifies you. If necessary, some of these records may be copied during these inspections. 

The results of this research study may be presented at meetings or in publications. However, you will not be personally identified in any presentations or publications.

The informed consent process provides you with the information required to ensure you make an informed decision about participation in the clinical research study. This process will: 

• Help you to understand the study
• Give you an opportunity to ask questions and to consider whether to participate 
• Obtain your voluntary agreement to participate
• Continue to provide information as the clinical research study progresses 

Before participating, we will take you through a written Informed Consent Form (ICF) that outlines important information to consider before joining the study. The study staff will go through this document with you and answer any questions you may have. This document provides details of the study, such as study expectations, duration, and what you will need to do. All known possible risks and potential benefits are also explained in the ICF. After you have read and discussed all the information about the study, you can decide whether or not to digitally sign the consent form. This consent form is not a contract, and you are always free to leave the study at any time and for any reason, with no penalty to you. Additionally, during your participation, the study staff will let you know in a timely manner of any information that may change your mind about participating.